The field of sustainable polymers from renewable feedstocks is a fast-reviving field after the decades-long domination of petroleum-based polymers. Amide-containing polymers exhibit a wide range of properties depending on the type of amide (primary, secondary, and tertiary), amide density, and other molecular structural parameters (co-existing groups, molecular weight, and topology). Engineering amide groups into sustainable polymers via the “monomer approach” is an industrially proven strategy, while bio-based monomers are of enormous importance to bridge the gap between renewable sources and amide-containing sustainable polymers (AmSPs). This feature article aims at conceptualizing the monomer-design philosophy behind most of the reported AmSPs and is organized by discussing di-functional monomers for step-growth polymerization, cyclic monomers for ring-opening polymerization and amide-containing monomers for chain-growth polymerization. We also give a perspective on AmSPs with respect to monomer design and performance enhancement.